Metabolic profiles of dioscin in rats revealed by ultra‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry

Dioscin (DIS), one of the most abundant bioactive steroidal saponins in Dioscorea sp., is used as a complementary medicine to treat coronary disease and angina pectoris in China. Although the pharmacological activities and pharmacokinetics of DIS have been well demonstrated, information regarding the final metabolic fates is very limited. This study investigated the in vivo metabolic profiles of DIS after oral administration by ultra‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry method. The structures of the metabolites were identified and tentatively characterized by means of comparing the molecular mass, retention time and fragmentation pattern of the analytes with those of the parent compound. A total of eight metabolites, including seven phase I and one phase II metabolites, were detected and tentatively identified for the first time. Oxidation, deglycosylation and glucuronidation were found to be the major metabolic processes of the compound in rats. In addition, a possible metabolic pathway on the biotransformation of DIS in vivo was proposed. This study provides valuable and new information on the metabolism of DIS, which will be helpful for further understanding its mechanism of action. Copyright © 2015 John Wiley & Sons, Ltd.     

Dimethyl [(3,5-di-tert-butyl-4-oxo-2,5-cyclohexadienylidene)-methyl]phosphonate in reactions with aliphatic diols

Russian Journal of General Chemistry -     

Thermodynamic analysis of a process for producing high-octane gasoline components from catalytic cracking gas

The results from a thermodynamic analysis of high-octane gasoline component production from catalytic cracking gases using zeolite catalyst OMNIKAT-210P modified with Ni, Co, Cr are presented. The equilibrium constants of the reactions assumed to occur in this process are calculated, along with the equilibrium yield of the reactions.     

Crack Tip Opening Angle as a Fracture Resistance Parameter to Describe Ductile Crack Extension and Arrest in Steel Pipes under Service Pressure

The angle between two element sides representing the crack tip is defined as the crack tip opening angle (CTOA). Its critical value is used as a criterion of fracture resistance for characterizing stable tearing in thin metallic materials. Various methods are used for determination of the CTOA. Optical microscopy is one of the most common methods as well as fitting of experimental load-displacement diagrams by the finite element method (DIC). Additionally, analytical analysis using the experimental load-displacement curve method (SSM) derived from the plastic hinge model of deflection in three-point bending of a ductile specimen is applied. This approach assumes a constant rotation centre distance. Values of CTOA for API 5L X65 pipe steel found by three methods—DIC, CNM, and SSM—are given. Values of CTOA given by these three methods are similar and close to 20°. A discussion on the different parameters used to characterize the fracture resistance of running cracks in a pipe under service pressure is presented. The energy of fracture at impact determined by Charpy or drop-weight tear test (DWTT) tests and the critical J energy parameter are considered as well as the yield locus after damage, cohesive zone energy, and CTOA is another approach. One notes that CTOA is assumed to be constant during stable crack extension and decreases linearly with crack length during the instable and primary phase. A numerical technique to describe a ductile running crack using the node release technique and using CTOA as the fracture resistance criterion is presented. This method is compared with three different two-curve methods (TCMs): the Battelle, high strength line pipe (HLP), and HLP-Sumitomo methods. The Batelle TCM, as the oldest method, based on Charpy energy, gives a strongly conservative prediction. Predictions by the CTOA method are close to those obtained by the HLP-Sumitomo one.     

干式变压器有限元仿真模型的电磁和振动分析

随着电力需求的逐年增长,干式变压器的数量也在不断增加。干式变压器在运行时存在着振动和噪声的问题,为了对干式变压器振动的规律与特点进行研究,本文建立了干式变压器本体振动的有限元仿真模型,通过电磁分析获得相应的磁场分布,然后利用结构动力学分析得到其本体振动的相关规律。通过对处于运行状态的变压器振动数据进行实测分析,得到变压器振动的特征频率,然后对仿真结果进行对比分析,可以发现振动幅度与频率之间存在的关系。本文的研究结果可对干式变压器的减振降噪研究提供参考。